Sakadzic Lab Publications

Harvard Catalyst
NCBI

        1. Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville ET, Guo S, Fu B, Alfadhel M, Allu SR, Sencan-Egilmez I, Li B, Ran C, Vinogradov SA, Ayata C, Lo E, Arai K, Devor A, Sakadžic S. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation. Elife. 2023 Jul 04; 12. PMID: 37402178.
        2. Sugimoto K, Yang J, Fischer P, Takizawa T, Mulder IA, Qin T, Erdogan TD, Yaseen MA, Sakadžic S, Chung DY, Ayata C. Optogenetic Spreading Depolarizations Do Not Worsen Acute Ischemic Stroke Outcome. Stroke. 2023 Apr; 54(4):1110-1119. PMID: 36876481.
        3. Li B, Yabluchanskiy A, Tarantini S, Allu SR, Sencan-Egilmez I, Leng J, Alfadhel MAH, Porter JE, Fu B, Ran C, Erdener SE, Boas DA, Vinogradov SA, Sonntag WE, Csiszar A, Ungvari Z, Sakadžic S. Measurements of cerebral microvascular blood flow, oxygenation, and morphology in a mouse model of whole-brain irradiation-induced cognitive impairment by two-photon microscopy and optical coherence tomography: evidence for microvascular injury in the cerebral white matter. Geroscience. 2023 Feb 16. PMID: 36792820.
        4. Pian Q, Alfadhel M, Tang J, Lee GV, Li B, Fu B, Ayata Y, Yaseen MA, Boas DA, Secomb TW, Sakadzic S. Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy. J Biomed Opt. 2023 Jul; 28(7):076003. PMID: 37484973.
        5. Li B, Leng J, Sencan-Egilmez I, Takase H, Alfadhel MAH, Fu B, Shahidi M, Lo EH, Arai K, Sakadžic S. Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion. Neurophotonics. 2023 Jul; 10(3):035001. PMID: 37323511.
        6. Mächler P, Fomin-Thunemann N, Thunemann M, Sætra MJ, Desjardins M, Kiliç K, Amra LN, Martin EA, Chen IA, Sencan-Egilmez I, Li B, Saisan P, Jiang JX, Cheng Q, Weldy KL, Boas DA, Buxton RB, Einevoll GT, Dale AM, Sakadžic S, Devor A. Baseline oxygen consumption decreases with cortical depth. PLoS Biol. 2022 10; 20(10):e3001440. PMID: 36301995; PMCID: PMC9642908.
        7. Aykan SA, Xie H, Zheng Y, Chung DY, Kura S, Han Lai J, Erdogan TD, Morais A, Tamim I, Yagmur D, Ishikawa H, Arai K, Abbas Yaseen M, Boas DA, Sakadzic S, Ayata C. Rho-Kinase Inhibition Improves the Outcome of Focal Subcortical White Matter Lesions. Stroke. 2022 07; 53(7):2369-2376. PMID: 35656825; PMCID: PMC9245195.
        8. Robinson MB, Renna M, Ozana NN, Peruch A, Sakadzic S, Blackwell ML, Richardson JM, Aull BF, Carp SA, Franceschini MA. Diffuse Correlation Spectroscopy Beyond the Water Peak Enabled by Cross-Correlation of the Signals From InGaAs/InP Single Photon Detectors. IEEE Trans Biomed Eng. 2022 06; 69(6):1943-1953. PMID: 34847015; PMCID: PMC9119938.
        9. Abdelfattah AS, Ahuja S, Akkin T, Allu SR, Brake J, Boas DA, Buckley EM, Campbell RE, Chen AI, Cheng X, Cižmár T, Costantini I, De Vittorio M, Devor A, Doran PR, El Khatib M, Emiliani V, Fomin-Thunemann N, Fainman Y, Fernandez-Alfonso T, Ferri CGL, Gilad A, Han X, Harris A, Hillman EMC, Hochgeschwender U, Holt MG, Ji N, Kiliç K, Lake EMR, Li L, Li T, Mächler P, Miller EW, Mesquita RC, Nadella KMNS, Nägerl UV, Nasu Y, Nimmerjahn A, Ondrácková P, Pavone FS, Perez Campos C, Peterka DS, Pisano F, Pisanello F, Puppo F, Sabatini BL, Sadegh S, Sakadzic S, Shoham S, Shroff SN, Silver RA, Sims RR, Smith SL, Srinivasan VJ, Thunemann M, Tian L, Tian L, Troxler T, Valera A, Vaziri A, Vinogradov SA, Vitale F, Wang LV, Uhlírová H, Xu C, Yang C, Yang MH, Yellen G, Yizhar O, Zhao Y. Neurophotonic tools for microscopic measurements and manipulation: status report. Neurophotonics. 2022 Jan; 9(Suppl 1):013001. PMID: 35493335; PMCID: PMC9047450.
        10. Oka F, Lee JH, Yuzawa I, Li M, von Bornstaedt D, Eikermann-Haerter K, Qin T, Chung DY, Sadeghian H, Seidel JL, Imai T, Vuralli D, Platt RM, Nelson MT, Joutel A, Sakadzic S, Ayata C. CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis. J Clin Invest. 2022 04 15; 132(8). PMID: 35202003; PMCID: PMC9012276.
        11. Oka F, Sadeghian H, Yaseen MA, Fu B, Kura S, Qin T, Sakadžic S, Sugimoto K, Inoue T, Ishihara H, Nomura S, Suzuki M, Ayata C. Intracranial pressure spikes trigger spreading depolarizations. Brain. 2022 03 29; 145(1):194-207. PMID: 34245240; PMCID: PMC9126007.
        12. Lai JH, Qin T, Sakadžic S, Ayata C, Chung DY. Cortical Spreading Depolarizations in a Mouse Model of Subarachnoid Hemorrhage. Neurocrit Care. 2022 06; 37(Suppl 1):123-132. PMID: 34981426; PMCID: PMC9250554.
        13. Aykan SA, Xie H, Lai JH, Zheng Y, Chung DY, Kura S, Anzabi M, Sugimoto K, McAllister LM, Yaseen MA, Boas DA, Whalen MJ, Sakadzic S, Ayata C. Focal Subcortical White Matter Lesions Disrupt Resting State Cortical Interhemispheric Functional Connectivity in Mice. Cereb Cortex. 2021 Oct 01; 31(11):4958-4969. PMID: 34037216.
        14. Liu C, Chisholm A, Fu B, Su CT, Sencan I, Sakadzic S, Yaseen MA. Quantitation of cerebral oxygen tension using phasor analysis and phosphorescence lifetime imaging microscopy (PLIM). Biomed Opt Express. 2021 Jul 01; 12(7):4192-4206. PMID: 34457408.
        15. Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadzic S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM. Circadian Biology and Stroke. Stroke. 2021 Jun; 52(6):2180-2190. PMID: 33940951.
        16. Anzabi M, Li B, Wang H, Kura S, Sakadzic S, Boas D, Østergaard L, Ayata C. Optical coherence tomography of arteriolar diameter and capillary perfusion during spreading depolarizations. J Cereb Blood Flow Metab. 2021 Sep; 41(9):2256-2263. PMID: 33593116.
        17. Mächler P, Broggini T, Mateo C, Thunemann M, Fomin-Thunemann N, Doran PR, Sencan I, Kilic K, Desjardins M, Uhlirova H, Yaseen MA, Boas DA, Linninger AA, Vergassola M, Yu X, Lewis LD, Polimeni JR, Rosen BR, Sakadzic S, Buxton RB, Lauritzen M, Kleinfeld D, Devor A. A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI. Curr Opin Biomed Eng. 2021 Jun; 18. PMID: 33959688.
        18. Bordoni L, Li B, Kura S, Boas DA, Sakadzic S, Østergaard L, Frische S, Gutiérrez-Jiménez E. Quantification of Capillary Perfusion in an Animal Model of Acute Intracranial Hypertension. J Neurotrauma. 2021 Feb 15; 38(4):446-454. PMID: 32998634.
        19. Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakadžic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985. PMID: 32936728.
        20. Fischer P, Sugimoto K, Chung DY, Tamim I, Morais A, Takizawa T, Qin T, Gomez CA, Schlunk F, Endres M, Yaseen MA, Sakadzic S, Ayata C. Rapid hematoma growth triggers spreading depolarizations in experimental intracortical hemorrhage. J Cereb Blood Flow Metab. 2021 06; 41(6):1264-1276. PMID: 32936730.
        21. Robinson M, Boas D, Sakadzic S, Franceschini MA, Carp S. Interferometric diffuse correlation spectroscopy improves measurements at long source-detector separation and low photon count rate. J Biomed Opt. 2020 09; 25(9). PMID: 33000571.
        22. Sætra MJ, Solbrå AV, Devor A, Sakadzic S, Dale AM, Einevoll GT. Spatially resolved estimation of metabolic oxygen consumption from optical measurements in cortex. Neurophotonics. 2020 Jul; 7(3):035005. PMID: 32855994.
        23. Secomb TW, Bullock KV, Boas DA, Sakadzic S. The mass transfer coefficient for oxygen transport from blood to tissue in cerebral cortex. J Cereb Blood Flow Metab. 2020 Aug; 40(8):1634-1646. PMID: 31423930.
        24. Sugimoto K, Chung DY, Böhm M, Fischer P, Takizawa T, Aslihan Aykan S, Qin T, Yanagisawa T, Harriott A, Oka F, Yaseen MA, Sakadzic S, Ayata C. Peri-Infarct Hot-Zones Have Higher Susceptibility to Optogenetic Functional Activation-Induced Spreading Depolarizations. Stroke. 2020 Aug; 51(8):2526-2535. PMID: 32640946.
        25. Sencan I, Esipova T, Kiliç K, Li B, Desjardins M, Yaseen MA, Wang H, Porter JE, Kura S, Fu B, Secomb TW, Boas DA, Vinogradov SA, Devor A, Sakadzic S. Optical measurement of microvascular oxygenation and blood flow responses in awake mouse cortex during functional activation. J Cereb Blood Flow Metab. 2020 Jun 09; 271678X20928011. PMID: 32515672.
        26. Celaya-Alcala JT, Lee GV, Smith AF, Li B, Sakadzic S, Boas DA, Secomb TW. Simulation of oxygen transport and estimation of tissue perfusion in extensive microvascular networks: Application to cerebral cortex. J Cereb Blood Flow Metab. 2020 Jun 05; 271678X20927100. PMID: 32501155.
        27. Esposito E, Li W, T Mandeville E, Park JH, Sencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadzic S, Ji X, Lo EH. Potential circadian effects on translational failure for neuroprotection. Nature. 2020 Jun; 582(7812):395-398. PMID: 32494010.
        28. Robinson MB, Carp SA, Peruch A, Boas DA, Franceschini MA, Sakadzic S. Characterization of continuous wave ultrasound for acousto-optic modulated diffuse correlation spectroscopy (AOM-DCS). Biomed Opt Express. 2020 Jun 01; 11(6):3071-3090. PMID: 32637242.
        29. Ahn SJ, Ruiz-Uribe NE, Li B, Porter J, Sakadzic S, Schaffer CB. Label-free assessment of hemodynamics in individual cortical brain vessels using third harmonic generation microscopy. Biomed Opt Express. 2020 May 01; 11(5):2665-2678. PMID: 32499951.
        30. Erdener SE, Tang J, Kiliç K, Postnov D, Giblin JT, Kura S, Chen IA, Vayisoglu T, Sakadzic S, Schaffer CB, Boas DA. Dynamic capillary stalls in reperfused ischemic penumbra contribute to injury: A hyperacute role for neutrophils in persistent traffic jams. J Cereb Blood Flow Metab. 2020 Apr 01; 271678X20914179. PMID: 32237951.
        31. Plunkett S, El Khatib M, Sencan I, Porter JE, Kumar ATN, Collins JE, Sakadzic S, Vinogradov SA. In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing. Nanoscale. 2020 Jan 28; 12(4):2657-2672. PMID: 31939953.
        32. Xie H, Chung DY, Kura S, Sugimoto K, Aykan SA, Wu Y, Sakadzic S, Yaseen MA, Boas DA, Ayata C. Differential effects of anesthetics on resting state functional connectivity in the mouse. J Cereb Blood Flow Metab. 2020 Apr; 40(4):875-884. PMID: 31092086.
        33. Böhm M, Chung DY, Gómez CA, Qin T, Takizawa T, Sadeghian H, Sugimoto K, Sakadzic S, Yaseen MA, Ayata C. Neurovascular coupling during optogenetic functional activation: Local and remote stimulus-response characteristics, and uncoupling by spreading depression. J Cereb Blood Flow Metab. 2020 Apr; 40(4):808-822. PMID: 31063009.
        34. Li B, Ohtomo R, Thunemann M, Adams SR, Yang J, Fu B, Yaseen MA, Ran C, Polimeni JR, Boas DA, Devor A, Lo EH, Arai K, Sakadzic S. Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion. J Cereb Blood Flow Metab. 2020 Mar; 40(3):501-512. PMID: 30829101.
        35. Sadegh S, Yang MH, Ferri CGL, Thunemann M, Saisan PA, Wei Z, Rodriguez EA, Adams SR, Kiliç K, Boas DA, Sakadzic S, Devor A, Fainman Y. Efficient non-degenerate two-photon excitation for fluorescence microscopy. Opt Express. 2019 Sep 30; 27(20):28022-28035. PMID: 31684560.
        36. Shvedova M, Litvak MM, Roberts JD, Fukumura D, Suzuki T, Sencan I, Li G, Reventun P, Buys ES, Kim HH, Sakadzic S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 12; 39(12):2379-2391. PMID: 31423931.  
        37. Cheng X, Berman AJL, Polimeni JR, Buxton RB, Gagnon L, Devor A, Sakadžic S, Boas DA. Dependence of the MR signal on the magnetic susceptibility of blood studied with models based on real microvascular networks. Magn Reson Med. 2019 06; 81(6):3865-3874. PMID: 30659643.
        38. Cheng X, Li Y, Mertz J, Sakadzic S, Devor A, Boas DA, Tian L. Development of a beam propagation method to simulate the point spread function degradation in scattering media. Opt Lett. 2019 Oct 15; 44(20):4989-4992. PMID: 31613246.
        39. Li B, Lu X, Moeini M, Sakadzic S, Thorin E, Lesage F. Atherosclerosis is associated with a decrease in cerebral microvascular blood flow and tissue oxygenation. PLoS One. 2019; 14(8):e0221547. PMID: 31469849.
        40. Li B, Esipova TV, Sencan I, Kiliç K, Fu B, Desjardins M, Moeini M, Kura S, Yaseen MA, Lesage F, Østergaard L, Devor A, Boas DA, Vinogradov SA, Sakadzic S. More homogeneous capillary flow and oxygenation in deeper cortical layers correlate with increased oxygen extraction. Elife. 2019 Jul 15; 8. PMID: 31305237.
        41. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 Mar 01; 29(3):1150-1161. PMID: 29425263.
        42. Gómez CA, Fu B, Sakadzic S, Yaseen MA. Cerebral metabolism in a mouse model of Alzheimer’s disease characterized by two-photon fluorescence lifetime microscopy of intrinsic NADH. Neurophotonics. 2018 Oct; 5(4):045008. PMID: 30603656.
        43. Desjardins M, Kiliç K, Thunemann M, Mateo C, Holland D, Ferri CGL, Cremonesi JA, Li B, Cheng Q, Weldy KL, Saisan PA, Kleinfeld D, Komiyama T, Liu TT, Bussell R, Wong EC, Scadeng M, Dunn AK, Boas DA, Sakadzic S, Mandeville JB, Buxton RB, Dale AM, Devor A. Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen-Level Dependent Functional Magnetic Resonance Imaging. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018 Dec 12. PMID: 30691968.
        44. Damseh R, Pouliot P, Gagnon L, Sakadzic S, Boas D, Cheriet F, Lesage F. Automatic Graph-based Modeling of Brain Microvessels Captured with Two-Photon Microscopy. IEEE J Biomed Health Inform. 2018 Dec 03. PMID: 30507542.
        45. Sencan I, Esipova TV, Yaseen MA, Fu B, Boas DA, Vinogradov SA, Shahidi M, Sakadzic S. Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice. J Biomed Opt. 2018 Dec; 23(12):1-9. PMID: 30516039.
        46. Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadzic S, Ayata C Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 Nov 01; 309:143-146. PMID: 30194041.View in: PubMed
        47. Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nat Protoc. 2018 Jun; 13(6):1377-1402. PMID: 29844521. View in: PubMed
        48. Gomez CA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžic S, Yaseen MA. Phasor analysis of NADH FLIM identifies pharmacological disruptions to mitochondrial metabolic processes in the rodent cerebral cortex. PLoS One. 2018; 13(3):e0194578. PMID: 29561904. View in: PubMed
        49. Kura S, Xie H, Fu B, Ayata C, Boas DA, Sakadzic S. Intrinsic optical signal imaging of the blood volume changes is sufficient for mapping the resting state functional connectivity in the rodent cortex. J Neural Eng. 2018 Feb 16. PMID: 29451130. View in: PubMed
        50. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2018 Feb 07. PMID: 29425263. View in: PubMed
        51. Wang H, Magnain C, Sakadzic S, Fischl B, Boas DA. Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography. Biomed Opt Express. 2017 Dec 01; 8(12):5617-5636. PMID: 29296492. View in: PubMed
        52. Tang J, Erdener SE, Li B, Fu B, Sakadzic S, Carp SA, Lee J, Boas DA. Shear-induced diffusion of red blood cells measured with dynamic light scattering-optical coherence tomography. J Biophotonics. 2017 Jul 12. PMID: 28700129. View in: PubMed
        53. Rasmussen PM, Smith AF, Sakadžic S, Boas DA, Pries AR, Secomb TW, Østergaard L. Model-based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach. Microcirculation. 2017 May; 24(4). PMID: 27987383.View in: PubMed
        54. Yaseen MA, Sutin J, Wu W, Fu B, Uhlirova H, Devor A, Boas DA, Sakadžic S. Fluorescence lifetime microscopy of NADH distinguishes alterations in cerebral metabolism in vivo. Biomed Opt Express. 2017 May 01; 8(5):2368-2385. PMID: 28663879.View in: PubMed
        55. Sakadžic S, Boas DA, Carp S. Theoretical model of blood flow measurement by diffuse correlation spectroscopy. J Biomed Opt. 2017 02 01; 22(2):27006. PMID: 28241276.View in: PubMed
        56. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. PMID: 28135240.View in: PubMed
        57. Li B, Wang H, Fu B, Wang R, Sakadžic S, Boas DA. Impact of temporal resolution on estimating capillary RBC-flux with optical coherence tomography. J Biomed Opt. 2017 01 01; 22(1):16014. PMID: 28125157.View in: PubMed
        58. Xu K, Boas DA, Sakadžic S, LaManna JC. Brain Tissue PO2 Measurement During Normoxia and Hypoxia Using Two-Photon Phosphorescence Lifetime Microscopy. Adv Exp Med Biol. 2017; 977:149-153. PMID: 28685439.View in: PubMed
        59. Pouliot P, Gagnon L, Lam T, Avti PK, Bowen C, Desjardins M, Kakkar AK, Thorin E, Sakadzic S, Boas DA, Lesage F. Magnetic resonance fingerprinting based on realistic vasculature in mice. Neuroimage. 2017 Apr 01; 149:436-445. PMID: 28043909.View in: PubMed
        60. Sakadžic S, Yaseen MA, Jaswal R, Roussakis E, Dale AM, Buxton RB, Vinogradov SA, Boas DA, Devor A. Two-photon microscopy measurement of cerebral metabolic rate of oxygen using periarteriolar oxygen concentration gradients. Neurophotonics. 2016 Oct; 3(4):045005. PMID: 27774493.View in: PubMed
        61. Uhlirova H, Kiliç K, Tian P, Sakadžic S, Gagnon L, Thunemann M, Desjardins M, Saisan PA, Nizar K, Yaseen MA, Hagler DJ, Vandenberghe M, Djurovic S, Andreassen OA, Silva GA, Masliah E, Kleinfeld D, Vinogradov S, Buxton RB, Einevoll GT, Boas DA, Dale AM, Devor A. The roadmap for estimation of cell-type-specific neuronal activity from non-invasive measurements. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 05; 371(1705). PMID: 27574309; PMCID: PMC5003857 [Available on 10/05/17]. View in: PubMed, PubMed Central
        62. Gagnon L, Sakadžic S, Lesage F, Pouliot P, Dale AM, Devor A, Buxton RB, Boas DA. Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy. Philos Trans R Soc Lond B Biol Sci. 2016 Oct 05; 371(1705). PMID: 27574311; PMCID: PMC5003859 [Available on 10/05/17]. View in: PubMed, PubMed Central
        63. Goergen CJ, Chen HH, Sakadžic S, Srinivasan VJ, Sosnovik DE. Microstructural characterization of myocardial infarction with optical coherence tractography and two-photon microscopy. Physiol Rep. 2016 Sep; 4(18). PMID: 27650248. View in: PubMed
        64. Gagnon L, Smith AF, Boas DA, Devor A, Secomb TW, Sakadžic S. Modeling of Cerebral Oxygen Transport Based on In vivo Microscopic Imaging of Microvascular Network Structure, Blood Flow, and Oxygenation. Front Comput Neurosci. 2016; 10:82. PMID: 27630556; PMCID: PMC5006088. View in: PubMed, PubMed Central
        65. Boas DA, Sakadžic S, Selb J, Farzam P, Franceschini MA, Carp SA. Establishing the diffuse correlation spectroscopy signal relationship with blood flow. Neurophotonics. 2016 Jul; 3(3):031412. PMID: 27335889; PMCID: PMC4904065 [Available on 06/13/17]. View in: PubMed, PubMed Central
        66. Uhlirova H, Kiliç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžic S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vandenberghe M, Cremonesi JA, Ferri CG, Nizar K, Sridhar VB, Steed TC, Abashin M, Fainman Y, Masliah E, Djurovic S, Andreassen OA, Silva GA, Boas DA, Kleinfeld D, Buxton RB, Einevoll GT, Dale AM, Devor A. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 2016 May 31; 5. PMID: 27244241; PMCID: PMC4933561. View in: PubMed, PubMed Central
        67. Wang H, Akkin T, Magnain C, Wang R, Dubb J, Kostis WJ, Yaseen MA, Cramer A, Sakadžic S, Boas D. Polarization sensitive optical coherence microscopy for brain imaging. Opt Lett. 2016 May 15; 41(10):2213-6. PMID: 27176965.View in: PubMed
        68. Magnain C, Wang H, Sakadžic S, Fischl B, Boas DA. En face speckle reduction in optical coherence microscopy by frequency compounding. Opt Lett. 2016 May 01; 41(9):1925-8. PMID: 27128040. View in: PubMed
        69. Gutiérrez-Jiménez E, Cai C, Mikkelsen IK, Rasmussen PM, Angleys H, Merrild M, Mouridsen K, Jespersen SN, Lee J, Iversen NK, Sakadzic S, Østergaard L. Effect of electrical forepaw stimulation on capillary transit-time heterogeneity (CTH). J Cereb Blood Flow Metab. 2016 Dec; 36(12):2072-2086. PMID: 26858243. View in: PubMed
        70. Yaseen MA, Srinivasan VJ, Gorczynska I, Fujimoto JG, Boas DA, Sakadžic S. Multimodal optical imaging system for in vivo investigation of cerebral oxygen delivery and energy metabolism. Biomed Opt Express. 2015 Dec 01; 6(12):4994-5007. PMID: 26713212; PMCID: PMC4679272. View in: PubMed, PubMed Central
        71. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156; PMCID: PMC4821018 [Available on 04/01/17]. View in: PubMed, PubMed Central
        72. Sakadžic S. At long last, PAT hats for the lab rats. J Cereb Blood Flow Metab. 2015 Aug; 35(8):1223. PMID: 26082018; PMCID: PMC4527998. View in: PubMed, PubMed Central
        73. Sakadžic S, Lee J, Boas DA, Ayata C. High-resolution in vivo optical imaging of stroke injury and repair. Brain Res. 2015 Oct 14; 1623:174-92. PMID: 25960347; PMCID: PMC4569527 [Available on 10/14/16]. View in: PubMed, PubMed Central
        74. Gagnon L, Sakadžic S, Lesage F, Mandeville ET, Fang Q, Yaseen MA, Boas DA. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography. Neurophotonics. 2015 Jan; 2(1):015008. PMID: 26157987; PMCID: PMC4478873. View in: PubMed, PubMed Central
        75. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA, Moskowitz MA, Lo EH, Dreier JP, Woitzik J, Sakadžic S, Ayata C. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 04; 85(5):1117-31. PMID: 25741731; PMCID: PMC4351476. View in: PubMed, PubMed Central
        76. Gagnon L, Sakadžic S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. J Neurosci. 2015 Feb 25; 35(8):3663-75. PMID: 25716864; PMCID: PMC4339366. View in: PubMed, PubMed Central
        77. Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžic S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B. Optical coherence tomography visualizes neurons in human entorhinal cortex. Neurophotonics. 2015 Feb 09; 2(1):015004. PMID: 25741528. View in: PubMed
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        79. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761; PMCID: PMC3737090. View in: PubMed, PubMed Central
        80. Nizar K, Uhlirova H, Tian P, Saisan PA, Cheng Q, Reznichenko L, Weldy KL, Steed TC, Sridhar VB, MacDonald CL, Cui J, Gratiy SL, Sakadzic S, Boas DA, Beka TI, Einevoll GT, Chen J, Masliah E, Dale AM, Silva GA, Devor A. In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci. 2013 May 08; 33(19):8411-22. PMID: 23658179; PMCID: PMC3712855. View in: PubMed, PubMed Central
        81. Yaseen MA, Sakadžic S, Wu W, Becker W, Kasischke KA, Boas DA. In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH. Biomed Opt Express. 2013 Feb 01; 4(2):307-21. PMID: 23412419; PMCID: PMC3567717. View in: PubMed, PubMed Central
        82. Esipova TV, Ye X, Collins JE, Sakadžic S, Mandeville ET, Murray CB, Vinogradov SA. Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20826-31. PMID: 23213211; PMCID: PMC3529031. View in: PubMed, PubMed Central
        83. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4. PMID: 23041891; PMCID: PMC3691965. View in: PubMed, PubMed Central
        84. Devor A, Sakadžic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1259-76. PMID: 22252238; PMCID: PMC3390808. View in: PubMed, PubMed Central
        85. Yuzawa I, Sakadžic S, Srinivasan VJ, Shin HK, Eikermann-Haerter K, Boas DA, Ayata C. Cortical spreading depression impairs oxygen delivery and metabolism in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):376-86. PMID: 22008729; PMCID: PMC3272607. View in: PubMed, PubMed Central
        86. Baraghis E, Devor A, Fang Q, Srinivasan VJ, Wu W, Lesage F, Ayata C, Kasischke KA, Boas DA, Sakadzic S. Two-photon microscopy of cortical NADH fluorescence intensity changes: correcting contamination from the hemodynamic response. J Biomed Opt. 2011 Oct; 16(10):106003. PMID: 22029350; PMCID: PMC3206923. View in: PubMed, PubMed Central
        87. Devor A, Sakadzic S, Saisan PA, Yaseen MA, Roussakis E, Srinivasan VJ, Vinogradov SA, Rosen BR, Buxton RB, Dale AM, Boas DA. “Overshoot” of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels. J Neurosci. 2011 Sep 21; 31(38):13676-81. PMID: 21940458; PMCID: PMC3188944. View in: PubMed, PubMed Central
        88. Carp SA, Roche-Labarbe N, Franceschini MA, Srinivasan VJ, Sakadžic S, Boas DA. Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels. Biomed Opt Express. 2011 Jul 01; 2(7):2047-54. PMID: 21750779; PMCID: PMC3130588. View in: PubMed, PubMed Central
        89. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. J. Vis. Exp. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. 2011; (51).
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        91. Yaseen MA, Srinivasan VJ, Sakadžic S, Radhakrishnan H, Gorczynska I, Wu W, Fujimoto JG, Boas DA. Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation. J Cereb Blood Flow Metab. 2011 Apr; 31(4):1051-63. PMID: 21179069; PMCID: PMC3070982. View in: PubMed, PubMed Central
        92. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997; PMCID: PMC2932799. View in: PubMed, PubMed Central
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        94. Sukhotinsky I, Yaseen MA, Sakadzic S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1168-77. PMID: 20087371; PMCID: PMC2921789. View in: PubMed, PubMed Central
        95. Yaseen MA, Srinivasan VJ, Sakadzic S, Wu W, Ruvinskaya S, Vinogradov SA, Boas DA. Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy. Opt Express. 2009 Dec 07; 17(25):22341-50. PMID: 20052157; PMCID: PMC2857779. View in: PubMed, PubMed Central
        96. Srinivasan VJ, Sakadzic S, Gorczynska I, Ruvinskaya S, Wu W, Fujimoto JG, Boas DA. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography. Opt Lett. 2009 Oct 15; 34(20):3086-8. PMID: 19838234; PMCID: PMC2778254. View in: PubMed, PubMed Central
        97. Lebedev AY, Cheprakov AV, Sakadzic S, Boas DA, Wilson DF, Vinogradov SA. Dendritic phosphorescent probes for oxygen imaging in biological systems. ACS Appl Mater Interfaces. 2009 Jun; 1(6):1292-304. PMID: 20072726; PMCID: PMC2805241. View in: PubMed, PubMed Central
        98. Sakadzic S, Yuan S, Dilekoz E, Ruvinskaya S, Vinogradov SA, Ayata C, Boas DA. Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt. 2009 Apr 01; 48(10):D169-77. PMID: 19340106; PMCID: PMC2692697. View in: PubMed, PubMed Central
        99. Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 08; 16(25):20848-63. PMID: 19065223; PMCID: PMC2689708. View in: PubMed, PubMed Central
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        101. Sakadzic S, Wang LV. Correlation transfer equation for multiply scattered light modulated by an ultrasonic pulse. J Opt Soc Am A Opt Image Sci Vis. 2007 Sep; 24(9):2797-806. PMID: 17767248. View in: PubMed
        102. Kothapalli SR, Sakadzic S, Kim C, Wang LV. Imaging optically scattering objects with ultrasound-modulated optical tomography. Opt Lett. 2007 Aug 15; 32(16):2351-3. PMID: 17700782. View in: PubMed
        103. Sakadzic S, Wang LV. Correlation transfer equation for ultrasound-modulated multiply scattered light. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Sep; 74(3 Pt 2):036618. PMID: 17025775. View in: PubMed
        104. Zemp R, Sakadzic S, Wang LV. Stochastic explanation of speckle contrast detection in ultrasound-modulated optical tomography. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun; 73(6 Pt 1):061920. PMID: 16906877. View in: PubMed
        105. Sakadzic S, Wang LV. Correlation transfer and diffusion of ultrasound-modulated multiply scattered light. Phys Rev Lett. 2006 Apr 28; 96(16):163902. PMID: 16712231. View in: PubMed
        106. Sakadzic S, Wang LV. Modulation of multiply scattered coherent light by ultrasonic pulses: an analytical model. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Sep; 72(3 Pt 2):036620. PMID: 16241605. View in: PubMed
        107. Sakadzic S, Wang LV. High-resolution ultrasound-modulated optical tomography in biological tissues. Opt Lett. 2004 Dec 01; 29(23):2770-2. PMID: 15605500. View in: PubMed
        108. Petrovic ZL, Sakadzic S, Spasojevic N, Matsui J, Makabe T. Mater. Sci. Forum. Comparison of direct numerical procedure and Monte Carlo technique to determine the charging effects in submicron structures. 2004; 453-454:9-14.
        109. Li J, Sakadzic S, Ku G, Wang LV. Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues. Appl Opt. 2003 Jul 01; 42(19):4088-94. PMID: 12868851. View in: PubMed
        110. Rahman A, Hammarsten EC, Sakadzic S, Rocca JJ, Wyart JF. Physica Scripta. Identification of n=4, Delta n=0 transitions in the spectra of nickel-like cadmium ions from a capillary discharge plasma column. 2003; 67(5):414-419. View Publication
        111. Sakadzic S, Wang LV. Ultrasonic modulation of multiply scattered coherent light: an analytical model for anisotropically scattering media. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug; 66(2 Pt 2):026603. PMID: 12241307. View in: PubMed
        112. Raspopovic Z, Sakadzic S, Petrovic ZL, Makabe T. J. Phys. D: Appl. Phys. Diffusion of electrons in time-dependent E(t) x B(t) fields. 2000; 33(11):1298-1302. View Publication
        113. Dyatko NA, Napartovich AP, Sakadzic S, Petrovic Z, Raspopovic Z. J. Phys. D: Appl. Phys. On the possibility of negative electron mobility in a decaying plasma. 2000; 33(4):375-380. View Publication
        114. Raspopovic Z, Sakadzic S, Bzenic SA, Petrovic ZL. IEEE Trans. Plasma Sci. Benchmark calculations for Monte Carlo simulations of electron transport. 1999; 27(5):1241-1248.
        115. Bzenic S, Raspopovic ZM, Sakadzic S, Petrovic ZL. IEEE Trans. Plasma Sci. Relaxation of electron swarm energy distribution functions in time-varying fields. 1999; 27(1):78-79.

      Book Chapters:

        • Kilic K, Uhlirova H, Tian P, Saisan PA, Yaseen MA, Lee J, Vinogradov SA, Boas DA, Sakadzic S, Devor A. Neurobiological Basis of Migraine. Dalkara T, Moskowitz MA editors. Tools for High-Resolution in vivo Imaging of Cellular and Molecular Mechanisms in Cortical Spreading Depression and Spreading Depolarization. 2017; 307-320.
        • Devor A, Sakadzic S, Yaseen MA, Roussakis E, Tian P, Slovin H, Vanzetta I, Teng IC, Saisan PA, Sinks LE, Dale AM, Vinogradov SA, Boas DA. “Optical imaging of cortical circuit dynamics” in Neuromethods, vol. 85, Bruno Weber and Fritjof Helmchen, Editors. Functional Imaging of Cerebral Oxygenation with Intrinsic Optical Contrast and Phosphorescent Probes. 2014; 225-253.